Erratum to: J Biol Phys DOI 10.1007/s10867-016-9411-x The original version of the article was also updated to reflect the below changes. The Fig. 6 caption of this article should be: Fig. 6 Firing patterns of a mammalian neuron in response to changes in Nav conductance induced by hSOD1A4V. a At the baseline (see Methods), there is no predicted spontaneous firing as modeled using NEURON software (left; resting membrane potential −62 mV). Transition from silence to firing was observed first at a conductance of 0.29 Siemens/cm2 (right). b When the Nav conductance in the model is increased by 90% (from 0.25 to 0.475 Siemens/cm2, which is the mean increment in conductance recorded experimentally), the model fires spontaneously (left). When this conductance is further increased to 1.34 Siemens/cm2 (a 4.4-fold increase), the model is depolarized to −27 mV and becomes unexcitable (right). c This demonstrates dependence of firing frequency on Nav channel conductance, indicating that as the conductance increases there is a progressive increase in frequency until depolarization

中文翻译：

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勘误表：突变 SOD1 蛋白增加 Nav1.3 通道兴奋性

勘误表：J Biol Phys DOI 10.1007/s10867-016-9411-x 文章的原始版本也进行了更新以反映以下更改。这篇文章的图 6 标题应该是： 图 6 哺乳动物神经元响应 hSOD1A4V 诱导的导航电导变化的放电模式。a 在基线（参见方法），没有使用 NEURON 软件建模的预测自发放电（左；静息膜电位 -62 mV）。首先在 0.29 Siemens/cm2 的电导下观察到从沉默到触发的转变（右）。b 当模型中的导航电导增加 90%（从 0.25 到 0.475 Siemens/cm2，这是实验记录的电导平均增量）时，模型自发点火（左）。当该电导进一步增加到 1.34 Siemens/cm2（增加 4.4 倍）时，模型去极化到 -27 mV 并变得不可兴奋（右）。c 这表明发射频率对导航通道电导的依赖性，表明随着电导增加，频率逐渐增加直到去极化