Modification of proteins with the lipid palmitate, a process called palmitoylation, is important for the normal function of neuronal cells. However, most attention has focused on how palmitoylation regulates the targeting and trafficking of neurotransmitter receptors and non-enzymatic scaffold proteins. In this review we discuss recent studies that suggest that palmitoylation also plays additional roles in neurons by controlling the localization, interactions and perhaps even the activity of protein kinases that play key roles in physiological neuronal regulation and in neuropathological processes.

中文翻译：

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滑动信号：神经元激酶定位和活性的棕榈酰化依赖性控制。

用脂棕榈酸酯修饰蛋白质（称为棕榈酰化）的过程对于神经元细胞的正常功能很重要。然而，大多数注意力集中在棕榈酰化如何调节神经递质受体和非酶促支架蛋白的靶向和运输上。在这篇综述中，我们讨论了最近的研究，这些研究表明棕榈酰化还通过控制在生理神经元调节和神经病理过程中起关键作用的蛋白激酶的定位，相互作用甚至可能在神经元中发挥了其他作用。