Fatigue is a severe problem for many people living with Parkinson's disease (PD). Best estimates suggest that more than 50% of patients experience this debilitating symptom. Little is known about its etiology or treatment, making the understanding of fatigue a true unmet need. As part of the Parkinson's Disease Foundation Community Choice Research Program, patients, caregivers, and scientists attended a symposium on fatigue on 16 and 17 October 2014. We present a summary of that meeting, reviewing what is known about the diagnosis and treatment of fatigue, its physiology, and what we might learn from multiple sclerosis (MS), depression, and cancer-disorders in which fatigue figures prominently too. We conclude with focused recommendations to enhance our understanding and treatment of this prominent problem in PD.

中文翻译：

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帕金森病的疲劳：多学科研讨会的报告。


对于许多帕金森病 (PD) 患者来说，疲劳是一个严重的问题。最准确的估计表明，超过 50% 的患者会出现这种使人衰弱的症状。人们对疲劳的病因或治疗知之甚少，这使得了解疲劳成为真正的未满足的需求。作为帕金森病基金会社区选择研究计划的一部分，患者、护理人员和科学家参加了 2014 年 10 月 16 日至 17 日举行的疲劳研讨会。我们总结了该次会议，回顾了有关疲劳诊断和治疗的已知信息，它的生理学，以及我们可以从多发性硬化症（MS）、抑郁症和癌症疾病中学到什么，其中疲劳也很重要。最后，我们提出了有针对性的建议，以加强我们对帕金森病这一突出问题的理解和治疗。