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Birth and pathogenesis of rogue respiratory viruses.
Annual Review of Pathology: Mechanisms of Disease ( IF 36.2 ) Pub Date : 2014-11-26 , DOI: 10.1146/annurev-pathol-012414-040501
David Safronetz 1 , Heinz Feldmann , Emmie de Wit
Affiliation  

Emerging infectious diseases of zoonotic origin are shaping today's infectious disease field more than ever. In this article, we introduce and review three emerging zoonotic viruses. Novel hantaviruses emerged in the Americas in the mid-1990s as the cause of severe respiratory infections, designated hantavirus pulmonary syndrome, with case fatality rates of around 40%. Nipah virus emerged a few years later, causing respiratory infections and encephalitis in Southeast Asia, with case fatality rates ranging from 40% to more than 90%. A new coronavirus emerged in 2012 on the Arabian Peninsula with a clinical syndrome of acute respiratory infections, later designated as Middle East respiratory syndrome (MERS), and an initial case fatality rate of more than 40%. Our current state of knowledge on the pathogenicity of these three severe, emerging viral infections is discussed.

中文翻译:

流氓呼吸道病毒的出生和发病机理。

人畜共患病的新发传染病比以往任何时候都更能影响当今的传染病领域。在本文中,我们介绍并回顾了三种新兴的人畜共患病毒。新的汉坦病毒在1990年代中期在美洲出现,是引起严重呼吸道感染的原因,被称为汉坦病毒肺综合症,病死率约为40%。Nipah病毒在几年后出现,在东南亚引起呼吸道感染和脑炎,病死率从40%到90%以上不等。2012年,阿拉伯半岛出现了一种新的冠状病毒,其临床症状为急性呼吸道感染,后来被称为中东呼吸道综合症(MERS),初始病例死亡率超过40%。我们目前对这三种严重疾病的致病性的了解,
更新日期:2019-11-01
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