The surface properties of nanoparticles (NPs) dictate their interaction with the outside world. The use of precisely designed molecular ligands to control NP surface properties provides an important toolkit for modulating their interaction with biological systems, facilitating their use in biomedicine. In this review we will discuss the application of the atom-by-atom control provided by organic synthesis to the generation of engineered nanoparticles, with emphasis on how the functionalization of NPs with these "small" organic molecules (Mw < 1,000) can be used to engineer NPs for a wide range of applications.

中文翻译：

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利用有机合成的力量来设计纳米颗粒与生物系统的相互作用

纳米颗粒 (NP) 的表面特性决定了它们与外界的相互作用。使用精确设计的分子配体来控制纳米颗粒表面特性，为调节纳米颗粒与生物系统的相互作用提供了重要的工具包，促进了它们在生物医学中的应用。在这篇综述中，我们将讨论有机合成提供的逐原子​​控制在工程纳米颗粒生成中的应用，重点是如何使用这些“小”有机分子（Mw < 1,000）对纳米颗粒进行功能化为广泛的应用设计纳米颗粒。