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Anti-Müllerian hormone in serum and seminal plasma in comparison with other male fertility parameters.
Systems Biology in Reproductive Medicine ( IF 2.1 ) Pub Date : 2016-04-26 , DOI: 10.3109/19396368.2016.1161864
Radek Kucera 1 , Zdenka Ulcova-Gallova 2, 3 , Jindra Windrichova 1 , Petr Losan 3 , Ondrej Topolcan 1
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Anti-Müllerian hormone (AMH) is a factor most associated with female fertility and especially with the ovarian reserve. AMH is also used as a parameter of fertility in men as it arises from the epithelium of the seminiferous tubules that contain Sertoli cells which produce the AMH. To investigate the relationship between AMH production and sperm related parameters we compared the AMH levels in serum and seminal plasma between a group of healthy males (n=65) and male patients (n=68) of infertile couples with semen pathology. We assessed the following fertility parameters: sperm count (SC), presence of intra-acrosomal enzymes (IAE), and antispermatozoal antibodies (ASA). Infertile men were divided into four subgroups according to: SC less than 15 million, SC less than 15 million and lack of IAE, SC less than 15 million and presence of ASA, presence of all three pathological parameters. The mean AMH serum level in the healthy group was 6.95 ng/ml and no significant difference was observed in serum AMH levels. The mean AMH seminal plasma level in the healthy group was 14.21 ng/ml. We observed a statistically significant decrease in the group with a SC with less than 15 million (3.29 ng/ml, p=0.0001) sperm, in the group with SC less than 15 million sperm and lack of IAE (3.95 ng/ml, p=0.0046), and in the group with all three pathological parameters (2.65 ng/ml, p=<0.0001). No significant difference was observed in the group with SC less than 15 million sperm and ASA positivity (11.41 ng/ml, p=0.3171). In conclusion AMH serum levels do not correlate with any of the observed parameters. AMH levels in seminal plasma positively correlate with the pathological SC and with SC pathology and IAE together.

中文翻译:

与其他男性生育参数相比,血清和精浆中的抗苗勒氏管激素。

抗苗勒管激素(AMH)是与女性生育力尤其是卵巢储备最相关的因素。AMH也被用作男性的生育能力参数,因为它是由含有能产生AMH的支持细胞的生精小管的上皮产生的。为了研究AMH产生与精子相关参数之间的关系,我们比较了一组健康男性(n = 65)和男性精子病理患者(n = 68)之间血清和精浆中AMH的水平。我们评估了以下生育参数:精子计数(SC),体内的酶(IAE)和抗精子体抗体(ASA)的存在。不育症男子根据以下四个方面分为四个亚组:SC小于1500万,SC小于1500万和缺乏IAE,SC小于1500万和有ASA,所有三个病理参数的存在。健康组的平均AMH血清水平为6.95 ng / ml,血清AMH水平无明显差异。健康组的平均AMH精浆水平为14.21 ng / ml。我们观察到,精子少于1500万(3.29 ng / ml,p = 0.0001)的精子组,精子少于1500万和IAE缺乏(3.95 ng / ml,p的组)的统计学显着性降低。 = 0.0046),并且在具有所有三个病理参数(2.65 ng / ml,p = <0.0001)的组中。在SC少于1500万的精子和ASA阳性(11.41 ng / ml,p = 0.3171)的组中,未观察到显着差异。总之,AMH血清水平与任何观察到的参数均不相关。
更新日期:2019-11-01
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