Self-assembly of peptides can yield an array of well-defined nanostructures that are highly attractive nanomaterials for many biomedical applications such as drug delivery. Some of the advantages of self-assembled peptide nanostructures over other delivery platforms include their chemical diversity, biocompatibility, high loading capacity for both hydrophobic and hydrophilic drugs, and their ability to target molecular recognition sites. Furthermore, these self-assembled nanostructures could be designed with novel peptide motifs, making them stimuli-responsive and achieving triggered drug delivery at disease sites. The goal of this work is to present a comprehensive review of the most recent studies on self-assembled peptides with a focus on their "smart" activity for formation of targeted and responsive drug-delivery carriers.

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自组装肽纳米结构：用于靶向药物输送的智能纳米材料

肽的自组装可以产生一系列明确的纳米结构，这些纳米结构对于药物输送等许多生物医学应用来说是极具吸引力的纳米材料。与其他递送平台相比，自组装肽纳米结构的一些优点包括其化学多样性、生物相容性、疏水性和亲水性药物的高负载能力以及靶向分子识别位点的能力。此外，这些自组装纳米结构可以设计有新颖的肽基序，使它们具有刺激响应性并在疾病部位实现触发药物输送。这项工作的目标是对自组装肽的最新研究进行全面综述，重点关注其形成靶向和响应性药物递送载体的“智能”活性。