Cullin-RING ubiquitin ligases are the largest Ubiquitin ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic subunit and substrate-binding subunit. KLHL20 is a substrate-binding subunit of Cullin3 (Cul3) ubiquitin ligase. Recent studies have identified a number of substrates of KLHL20-based ubiquitin ligase. Through ubiquitination of these substrates, KLHL20 elicits diverse cellular functions, some of which are associated with human diseases. Furthermore, the functions, subcellular localizations, and expression of KLHL20 are regulated by several physiological and stressed signals, which allow KLHL20 to preferentially act on certain substrates to response to these signals. Here, we provide a summary of the functions and regulations of KLHL20 in several physiological processes and stress responses and its disease implications.

中文翻译：

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Cul3-KLHL20泛素连接酶：生理功能，应激反应和疾病影响。

Cullin-RING泛素连接酶是真核生物中最大的泛素连接酶家族，是多蛋白复合物。在这些复合物中，Cullin蛋白用作连接连接酶的两个功能模块（催化亚基和底物结合亚基）的支架。KLHL20是Cullin3（Cul3）泛素连接酶的底物结合亚基。最近的研究已经确定了许多基于KLHL20的泛素连接酶的底物。通过这些底物的泛素化，KLHL20引发了多种细胞功能，其中一些与人类疾病有关。此外，KLHL20的功能，亚细胞定位和表达受几种生理信号和应激信号调节，这使KLHL20优先作用于某些底物以响应这些信号。这里，