The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.

中文翻译：

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血管平滑肌收缩的机制和平滑肌疾病的药物治疗基础。

平滑肌细胞直接驱动血管壁的收缩，从而调节血管腔的大小。我们在这里回顾当前对激动剂，治疗剂和疾病调节血管平滑肌细胞收缩力的分子机制的理解，并将其置于全身功能范围内。我们还讨论了个性化医学的意义，并强调了特定的潜在靶分子，这些分子可能为调节血管功能的新疗法的未来发展提供机会。