With a view to estimating the prevalence and resistance patterns of CA-MRSA in one region of Serbia, we performed an analysis of MRSA isolates from healthy people and hospitalised patients. The detection of CA-MRSA was carried out by SCCmec typing. In MRSA isolates from hospitalised patients SCCmec types IV and V were found in 76% of the strains. Similar percentage (80%) of CA-MRSA genotypes was present in healthy people. SCCmec type V harbouring MRSA was the most successful clone. Higher prevalence of type V in hospitalised patients to that in healthy people (70% vs 54%) may indicate nosocomial transmissions in at least some hospital units. All MRSA strains from hospitalised patients were resistant to one or more non-β-lactam antibiotics while 52% were multi-resistant. In isolates from healthy people, 16% were sensitive to all non-β-lactam antibiotics and 40% were multi-resistant. Similar percentage of multi-resistant CA- and HA-genotypes occurred in a particular environment (53% vs 50% in hospitalised patients, and 37.5% vs 37.5% in healthy people) indicating selective pressure of antibiotics as a leading force conferring antibiotic resistance. High prevalence of CA-MRSA and high resistance rate both in hospitals and the community suggest that this pathogen has been present in the Pomoravlje Region, central Serbia for years.

中文翻译：

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在塞尔维亚的Pomoravlje地区，与社区相关的耐甲氧西林金黄色葡萄球菌的高患病率和耐药模式。

为了估计CA-MRSA在塞尔维亚一个地区的流行和耐药模式，我们对来自健康人和住院患者的MRSA分离株进行了分析。CA-MRSA的检测通过SCCmec分型进行。在住院患者的MRSA分离株中，有76％的菌株发现IV和V型SCCmec。健康人群中存在相似百分比（80％）的CA-MRSA基因型。带有MRSA的SCCmec V型是最成功的克隆。住院患者中V型患病率高于健康人（70％对54％），这可能表明至少某些医院单位发生了医院内传播。住院患者的所有MRSA菌株均对一种或多种非β-内酰胺类抗生素具有抗药性，而52％的患者具有多重抗药性。在与健康人隔离的情况下，16％的人对所有非β-内酰胺类抗生素敏感，而40％的人具有多重耐药性。在特定环境中，多耐药CA和HA基因型的百分比相似（住院患者中53％vs 50％，健康人中37.5％vs 37.5％），这表明抗生素的选择性压力是赋予抗生素耐药性的主导力量。在医院和社区中，CA-MRSA的高流行和高耐药率表明，这种病原体在塞尔维亚中部的Pomoravlje地区已经存在多年。