Actinomycetes, especially species of Streptomyces are prolific producers of pharmacologically significant compounds accounting for about 70% of the naturally derived antibiotics that are presently in clinical use. In this study, we used five solvents to extract the secondary metabolites from marine Streptomyces parvulus DOSMB-D105, which was isolated from the mangrove sediments of the South Andaman Islands. Among them, ethyl acetate crude extract showed maximum activity against 11 pathogenic bacteria and six fungi. Presence of bioactive compounds in the ethyl acetate extract was determined using GC-MS and the compounds detected in the ethyl acetate extract were matched with the National Institute of Standards and Technology (NIST) library. Totally eight compounds were identified and the prevalent compounds were 2 steroids, 2 alkaloids, 2 plasticizers, 1 phenolic and 1 alkane. Present study revealed that S. parvulus DOSMB-D105 is a promising species for the isolation of valuable bioactive compounds to combat pathogenic microbes.

中文翻译：

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分离自安达曼群岛红树林沉积物的链霉菌Dosmb-D105的抗菌活性和系统发育分析。

放线菌，特别是链霉菌属是药理学上重要的化合物的多产者，占目前临床使用的天然抗生素的约70％。在这项研究中，我们使用了五种溶剂从海洋小链霉菌DOSMB-D105中提取次级代谢产物，该菌株是从南安达曼群岛的红树林沉积物中分离出来的。其中，乙酸乙酯粗提物对11种病原菌和6种真菌表现出最大的活性。使用GC-MS测定乙酸乙酯提取物中是否存在生物活性化合物，并将乙酸乙酯提取物中检测到的化合物与美国国家标准技术研究院（NIST）库进行匹配。总共鉴定出8种化合物，其中最常见的化合物是2个类固醇，2个生物碱，2种增塑剂，1种酚醛和1种烷烃。目前的研究表明，细小链球菌DOSMB-D105是一种有前途的物种，可用于分离有价值的生物活性化合物来对抗病原微生物。