Highlights • Control of disease should balance the cost of management against its efficacy.• Uniform control throughout administrative regions is almost always sub-optimal.• Control in high-risk areas, informed by epidemiology and economics, is most efficient.

中文翻译：

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入侵病原体的管理应以流行病学而非行政边界为依据

要点 • 疾病控制应平衡管理成本与其功效。• 整个行政区域的统一控制几乎总是次优的。• 以流行病学和经济学为依据的高风险地区的控制是最有效的。