Protein- and peptide-based structural biopolymers are abundant building blocks of biological systems. Either in their natural forms, such as collagen, silk or fibronectin, or as related synthetic materials they can be used in various technologies. An emerging area is that of biomimetic materials inspired by protein-based biopolymers, which are made up of small molecules rather than macromolecules and can therefore be described as supramolecular polymers. These materials are very useful in biomedical applications because of their ability to imitate the extracellular matrix both in architecture and their capacity to signal cells. This article describes important features of the natural extracellular matrix and highlight how these features are being incorporated into biomaterials composed of biopolymers and supramolecular polymers. We particularly focus on the structures, properties, and functions of collagen, fibronectin, silk, and the supramolecular polymers inspired by them as biomaterials for regenerative medicine.

中文翻译：

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生物聚合物和超分子聚合物作为生物医学应用的生物材料。

基于蛋白质和肽的结构生物聚合物是生物系统的丰富构建模块。无论是天然形式，如胶原蛋白、丝或纤连蛋白，还是作为相关的合成材料，它们都可以用于各种技术。一个新兴领域是受蛋白质生物聚合物启发的仿生材料，它由小分子而不是大分子组成，因此可以被描述为超分子聚合物。这些材料在生物医学应用中非常有用，因为它们能够在结构上模仿细胞外基质以及向细胞发出信号的能力。本文描述了天然细胞外基质的重要特征，并重点介绍了如何将这些特征纳入由生物聚合物和超分子聚合物组成的生物材料中。我们特别关注胶原蛋白、纤连蛋白、丝以及受其启发的超分子聚合物作为再生医学生物材料的结构、性质和功能。