Abstract Radiometals play an important role in diagnostic and therapeutic radiopharmaceuticals. This field of radiochemistry is multidisciplinary, involving radiometal production, separation of the radiometal from its target, chelate design for complexing the radiometal in a biologically stable environment, specific targeting of the radiometal to its in vivo site, and nuclear imaging and/or radiotherapy applications of the resultant radiopharmaceutical. The critical importance of inorganic chemistry in the design and application of radiometal-containing imaging and therapy agents is described from a historical perspective to future directions.

中文翻译：

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核成像和放射治疗中的无机化学：当前和未来的方向


摘要 放射性金属在诊断和治疗放射性药物中发挥着重要作用。放射化学领域是多学科的，涉及放射性金属生产、放射性金属与其靶标的分离、在生物稳定环境中络合放射性金属的螯合物设计、放射性金属对其体内位点的特异性靶向以及核成像和/或放射治疗应用所得的放射性药物。从历史角度到未来方向描述了无机化学在含放射性金属成像和治疗剂的设计和应用中的至关重要性。