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A nanoporous gold membrane for sensing applications.
Sensing and Bio-Sensing Research ( IF 5.4 ) Pub Date : 2016-03-15 , DOI: 10.1016/j.sbsr.2016.01.001
Swe Zin Oo 1 , Gloria Silva 2 , Francesca Carpignano 2 , Adnane Noual 1 , Katrin Pechstedt 1 , Luis Mateos 1 , James A Grant-Jacob 1 , Bill Brocklesby 1 , Peter Horak 1 , Martin Charlton 3 , Stuart A Boden 3 , Tracy Melvin 4
Affiliation  

Design and fabrication of three-dimensionally structured, gold membranes containing hexagonally close-packed microcavities with nanopores in the base, are described. Our aim is to create a nanoporous structure with localized enhancement of the fluorescence or Raman scattering at, and in the nanopore when excited with light of approximately 600 nm, with a view to provide sensitive detection of biomolecules. A range of geometries of the nanopore integrated into hexagonally close-packed assemblies of gold micro-cavities was first evaluated theoretically. The optimal size and shape of the nanopore in a single microcavity were then considered to provide the highest localized plasmon enhancement (of fluorescence or Raman scattering) at the very center of the nanopore for a bioanalyte traversing through. The optimized design was established to be a 1200 nm diameter cavity of 600 nm depth with a 50 nm square nanopore with rounded corners in the base. A gold 3D-structured membrane containing these sized microcavities with the integrated nanopore was successfully fabricated and 'proof of concept' Raman scattering experiments are described.

中文翻译:

用于传感应用的纳米多孔金膜。

描述了三维结构的金膜的设计和制造,该金膜包含六角形密堆积的微腔体,基体中具有纳米孔。我们的目的是创建一种纳米孔结构,当被约600 nm的光激发时,在纳米孔处和纳米孔中局部增强荧光或拉曼散射,以提供对生物分子的灵敏检测。首先从理论上评估了纳米孔的几何形状范围,该几何孔集成到金微腔的六边形密堆积组件中。然后认为单个微腔中纳米孔的最佳尺寸和形状可为遍历生物分析物的纳米孔的最中心提供最高的局部等离激元增强(荧光或拉曼散射)。优化的设计被确定为直径为1200 nm的腔,深度为600 nm,具有50 nm的方形纳米孔,底部带有圆角。包含这些大小的微腔以及集成纳米孔的金3D结构膜已成功制备,并描述了“概念验证”拉曼散射实验。
更新日期:2019-11-01
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