Human papillomaviruses (HPVs) infect the epidermis as well as mucous membranes of humans. They are the causative agents of anogenital tract and some oropharyngeal cancers. Infections begin in the basal epithelia, where the viral genome replicates slowly along with its host cell. As infected cells begin to differentiate and progress toward the periphery, the virus drives proliferation in cells that would otherwise be quiescent. To uncouple differentiation from continued cellular propagation, HPVs express two oncoproteins, HPV E6 and E7. This review focuses on high-risk α-HPV E6, which in addition to supporting viral replication has transforming properties. HPV E6 promotes p53 degradation and activates telomerase, but the multifaceted oncoprotein has numerous other functions that are highlighted here.

中文翻译：

---

人乳头瘤病毒E6癌蛋白的新功能。

人乳头瘤病毒（HPV）感染人的表皮和粘膜。它们是生殖道和某些口咽癌的病原体。感染始于基底上皮细胞，那里的病毒基因组与其宿主细胞一起缓慢复制。随着被感染的细胞开始分化并向周边发展，病毒会驱动原本处于静止状态的细胞增殖。为了使分化与持续的细胞增殖脱钩，HPV表达两种癌蛋白，即HPV E6和E7。这篇综述的重点是高风险的α-HPVE6，它除了支持病毒复制外还具有转化特性。HPV E6促进p53降解并激活端粒酶，但是多方面的癌蛋白还具有许多其他功能，在此处重点介绍。