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Deep Recombination: RNA and ssDNA Virus Genes in DNA Virus and Host Genomes.
Annual Review of Virology ( IF 11.3 ) Pub Date : 2016-03-10 , DOI: 10.1146/annurev-virology-100114-055127
Kenneth M Stedman 1
Affiliation  

Viruses are notorious for rapidly exchanging genetic information between close relatives and with the host cells they infect. This exchange has profound effects on the nature and rapidity of virus and host evolution. Recombination between dsDNA viruses is common, as is genetic exchange between dsDNA viruses or retroviruses and host genomes. Recombination between RNA virus genomes is also well known. In contrast, genetic exchange across viral kingdoms, for instance between nonretroviral RNA viruses or ssDNA viruses and host genomes or between RNA and DNA viruses, was previously thought to be practically nonexistent. However, there is now growing evidence for both RNA and ssDNA viruses recombining with host dsDNA genomes and, more surprisingly, RNA virus genes recombining with ssDNA virus genomes. Mechanisms are still unclear, but this deep recombination greatly expands the breadth of virus evolution and confounds virus taxonomy.

中文翻译:

深度重组:DNA病毒和宿主基因组中的RNA和ssDNA病毒基因。

众所周知,病毒会在近亲之间以及与其感染的宿主细胞之间快速交换遗传信息。这种交换对病毒和宿主进化的性质和速度具有深远的影响。dsDNA病毒之间的重组很常见,dsDNA病毒或逆转录病毒与宿主基因组之间的遗传交换也很常见。RNA病毒基因组之间的重组也是众所周知的。相反,以前认为跨病毒界的基因交换,例如非逆转录病毒RNA病毒或ssDNA病毒与宿主基因组之间或RNA与DNA病毒之间的遗传交换实际上是不存在的。但是,现在越来越多的证据表明RNA和ssDNA病毒与宿主dsDNA基因组重组,更令人惊讶的是,RNA病毒基因与ssDNA病毒基因组重组。机制还不清楚,
更新日期:2015-11-06
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