Narcolepsy with cataplexy (NC) is a neurological sleep disorder characterized by very low or undetectable concentration of hypocretin-1 in the cerebrospinal fluid. It has been recently found that patients with NC have disturbed circadian pattern of blood pressure, with more frequent non-dipping, compared to healthy controls. It has been hypothesized that lack of hypocretin may lead to increase in nocturnal blood pressure. This increase may result also from disturbed sleep architecture regardless of the deficiency of hypocretin. The aim of this study was to compare changes in values of daytime and nighttime blood pressure in NC patients and in patients with disturbed nocturnal sleep due to other sleep disorders. We have retrospectively compared polysomnographic and clinical data of 8 NC patients and 7 age- and sex controls suffering from insomnia. We have compared sleep architecture, mean blood pressure values and dipping pattern in both groups. The groups did not differ in terms of disturbances of sleep architecture. We have not found any statistical differences in values of daytime and nocturnal blood pressure. Non-dipping was equally frequent in both groups (87.5 and 85.7 %). Our results suggest that observed abnormalities in circadian changes of blood pressure values result from disturbed sleep architecture than from deficiency of hypocretin. Patients with sleep disorders should be carefully observed for the presence of increased blood pressure and other vascular risk factors.

中文翻译：

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“非浸泡”在发作性睡病患者和失眠患者中同样常见

猝倒性发作性睡病 (NC) 是一种神经性睡眠障碍，其特征是脑脊液中下丘脑分泌素 1 的浓度非常低或检测不到。最近发现，与健康对照相比，NC 患者的血压昼夜节律模式受到干扰，更频繁地不下降。据推测，缺乏hypocretin可能会导致夜间血压升高。无论是否缺乏下丘脑分泌素，这种增加也可能是由于睡眠结构紊乱所致。本研究的目的是比较 NC 患者和因其他睡眠障碍而夜间睡眠受到干扰的患者白天和夜间血压值的变化。我们回顾性比较了 8 名患有失眠症的 NC 患者和 7 名年龄和性别对照者的多导睡眠图和临床数据。我们比较了两组的睡眠结构、平均血压值和浸渍模式。各组在睡眠结构紊乱方面没有差异。我们没有发现白天和夜间血压值的任何统计差异。两组的非浸渍频率相同（87.5% 和 85.7%）。我们的结果表明，观察到的血压值昼夜节律变化异常是由于睡眠结构紊乱而不是下丘脑分泌素缺乏所致。应仔细观察睡眠障碍患者是否存在血压升高和其他血管危险因素。我们没有发现白天和夜间血压值的任何统计差异。两组的非浸渍频率相同（87.5% 和 85.7%）。我们的结果表明，观察到的血压值昼夜节律变化异常是由于睡眠结构紊乱而不是下丘脑分泌素缺乏所致。应仔细观察睡眠障碍患者是否存在血压升高和其他血管危险因素。我们没有发现白天和夜间血压值的任何统计差异。两组的非浸渍频率相同（87.5% 和 85.7%）。我们的结果表明，观察到的血压值昼夜节律变化异常是由于睡眠结构紊乱而不是下丘脑分泌素缺乏所致。应仔细观察睡眠障碍患者是否存在血压升高和其他血管危险因素。