We present an innovative surface-enhanced Raman spectroscopy (SERS) sensor based on a biological-plasmonic hybrid nanostructure by self-assembling silver (Ag) nanoparticles into diatom frustules. The photonic-crystal-like diatom frustules provide a spatially confined electric field with enhanced intensity that can form hybrid photonic-plasmonic modes through the optical coupling with Ag nanoparticles. The experimental results demonstrate 4-6× and 9-12× improvement of sensitivities to detect the Raman dye for resonance and nonresonance SERS sensing, respectively. Such low-cost and high-sensitivity SERS sensors have significant potentials for label-free biosensing.

中文翻译：

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来自具有自组装等离子体纳米颗粒的纳米生物二氧化硅的表面增强拉曼光谱传感器。

我们提出了一种创新的表面增强拉曼光谱 (SERS) 传感器，该传感器基于生物等离子体混合纳米结构，通过将银 (Ag) 纳米粒子自组装成硅藻壳。光子晶体状硅藻壳提供强度增强的空间受限电场，可以通过与银纳米粒子的光耦合形成混合光子 - 等离子体模式。实验结果表明，用于共振和非共振 SERS 传感的拉曼染料检测灵敏度分别提高了 4-6 倍和 9-12 倍。这种低成本和高灵敏度的 SERS 传感器在无标记生物传感方面具有巨大的潜力。