Arboviruses are pathogens that widely affect the health of people in different communities around the world. Recently, a few successful approaches toward production of effective vaccines against some of these pathogens have been developed, but treatment and prevention of the resulting diseases remain a major health and research concern. The arbovirus infection and replication processes are complex, and many factors are involved in their regulation. Apoptosis, autophagy and the unfolded protein response (UPR) are three mechanisms that are involved in pathogenesis of many viruses. In this review, we focus on the importance of these pathways in the arbovirus replication and infection processes. We provide a brief introduction on how apoptosis, autophagy and the UPR are initiated and regulated, and then discuss the involvement of these pathways in regulation of arbovirus pathogenesis.

中文翻译：

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虫媒病毒复制和发病机制中的细胞凋亡、自噬和未折叠蛋白反应途径

虫媒病毒是广泛影响世界各地不同社区人们健康的病原体。最近，已经开发出一些成功的方法来生产针对其中一些病原体的有效疫苗，但由此产生的疾病的治疗和预防仍然是主要的健康和研究问题。虫媒病毒的感染和复制过程很复杂，其调控涉及许多因素。细胞凋亡、自噬和未折叠蛋白反应 (UPR) 是参与许多病毒发病机制的三种机制。在这篇综述中，我们关注这些途径在虫媒病毒复制和感染过程中的重要性。我们简要介绍了如何启动和调节细胞凋亡、自噬和 UPR，