The aim of this cross-sectional study was to evaluate the cardiovascular risk in patients with subclinical hypothyroidism (SH) and metabolic syndrome (MetS) components. The study included 60 patients with SH and a control group of 60 healthy volunteers, gender and age matched, with normal thyroid-stimulating hormone (TSH) and free thyroxin (FT4) concentration. The following measurements were made in all participants: TSH, FT4, thyroid peroxidase antibodies, anti-thyroglobulin antibodies, body mass index (BMI), waist circumference, blood pressure, fasting plasma glucose, total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides (TG), TC/HDL cholesterol and LDL/HDL cholesterol ratio, basal insulin level and homeostatic model assessment insulin resistance (HOMA-IR) index. MetS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III criteria. The results showed that the following indices were statistically significantly higher in the SH group: BMI (p < 0.05), diastolic blood pressure (p < 0.001), TC (p < 0.05), TG (p < 0.05) and basal insulin level (p < 0.05). Although MetS parameters were present in a higher per cent in the SH group, there was a significantly higher number of patients with hypertension and decreased HDL cholesterol (p < 0.05). More frequently, MetS was diagnosed in SH patients (46.67%) than in the control group (33.33%), although the difference was not statistically significant. These results indicated that the traditional cardiovascular risk factors were more frequently present in SH patients as compared to euthyroid participants. Our results did not confirm significantly higher presence of MetS in SH patients in comparison with euthyroid respondents.

中文翻译：

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亚临床甲状腺功能减退症：与心血管危险因素和代谢综合征组成部分的关联


这项横断面研究的目的是评估亚临床甲状腺功能减退症 (SH) 和代谢综合征 (MetS) 患者的心血管风险。该研究包括 60 名 SH 患者和 60 名健康志愿者组成的对照组，性别和年龄匹配，促甲状腺激素 (TSH) 和游离甲状腺素 (FT4) 浓度正常。对所有参与者进行以下测量：TSH、FT4、甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体、体重指数（BMI）、腰围、血压、空腹血糖、总胆固醇（TC）、低密度脂蛋白（ LDL）胆固醇、高密度脂蛋白（HDL）胆固醇、甘油三酯（TG）、TC/HDL胆固醇和LDL/HDL胆固醇比值、基础胰岛素水平和稳态模型评估胰岛素抵抗（HOMA-IR）指数。 MetS 是根据国家胆固醇教育计划成人治疗小组 III 标准诊断的。结果显示，SH组的以下指标具有统计学意义：BMI（p < 0.05）、舒张压（p < 0.001）、TC（p < 0.05）、TG（p < 0.05）和基础胰岛素水平（p < 0.05）。 p < 0.05）。尽管 SH 组中 MetS 参数的比例较高，但患有高血压和 HDL 胆固醇降低的患者数量显着增加 (p < 0.05)。 SH 患者 (46.67%) 比对照组 (33.33%) 更频繁地诊断出 MetS，但差异无统计学意义。这些结果表明，与甲状腺功能正常的参与者相比，传统心血管危险因素在 SH 患者中更常见。我们的结果并未证实 SH 患者中 MetS 的存在率明显高于甲状腺功能正常的受访者。