Integrins are a group of heterodimeric transmembrane receptors that play essential roles in cell-cell and cell-matrix interaction. Integrins are important in many physiological processes and diseases. Integrins acquire affinity to their ligand by undergoing molecular conformational changes called activation. Here we review the molecular biomechanics during conformational changes of integrins, integrin functions in leukocyte biorheology (adhesive functions during rolling and arrest) and molecules involved in integrin activation.

中文翻译：

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白细胞停滞：β2整合素激活的生物力学和分子机制。

整联蛋白是一组异二聚跨膜受体，它们在细胞-细胞和细胞-基质相互作用中起重要作用。整联蛋白在许多生理过程和疾病中很重要。整联蛋白通过经历称为激活的分子构象变化而获得对其配体的亲和力。在这里，我们综述了整联蛋白构象变化过程中的分子生物力学，白细胞生物流变学中的整联蛋白功能（滚动和阻滞过程中的黏附功能）以及参与整联蛋白激活的分子。