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Therapeutic Effect of Adipose Derived Stem Cells versus Atorvastatin on Amiodarone Induced Lung Injury in Male Rat.
International Journal of Stem Cells ( IF 2.5 ) Pub Date : 2015-12-4 , DOI: 10.15283/ijsc.2015.8.2.170
Gihan Ibrahim Aboul-Fotouh 1 , Maha Baligh Zickri 1 , Hala Gabr Metwally 2 , Ihab Refaat Ibrahim 1 , Samaa Samir Kamar 1 , Wael Sakr 3
Affiliation  

Amiodarone (AM), a class 3 antiarrhythmic drug, has been associated with variety of adverse effects, the most serious of which is pulmonary toxicity. Ator (A) is a statin, known for their immunomodulatory and anti-inflammatory activities. Recent studies provide evidence of potential therapeutic effect of statins on lung injury. Adipose derived stem cells (ADSCs) have shown great promise in the repair of various tissues. The present study aimed at investigating and comparing the possible therapeutic effect of A and ADSCs on AM induced lung injury in albino rats.

中文翻译:

脂肪干细胞与阿托伐他汀对胺碘酮致雄性大鼠肺损伤的治疗作用。

胺碘酮(AM)是3类抗心律不齐药物,已引起多种不良反应,其中最严重的是肺毒性。Ator(A)是他汀类药物,以其免疫调节和抗炎活性而著称。最近的研究提供了他汀类药物对肺损伤的潜在治疗作用的证据。脂肪干细胞(ADSCs)在修复各种组织中显示出巨大的希望。本研究旨在调查和比较A和ADSCs对白化病大鼠AM诱导的肺损伤的可能治疗作用。
更新日期:2020-08-21
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