BackgroundMicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnosis of M. tuberculosis infection and successful treatment are of major importance.ConclusionsThis review summarizes recent surrogate tissue studies for identification of miRNA biomarker candidates in human tuberculosis with a special focus on reproducibility and conformance. In addition we provide assistance for the design of biomarker studies to circumvent major pitfalls.

中文翻译：

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microRNA 是否适合作为肺结核免疫的生物标志物？

背景微RNA (miRNA) 是人类免疫的关键调节剂，例如抗结核分枝杆菌。在结核病的高死亡率仍然令人担忧的背景下，有效的生物标志物对于改善结核分枝杆菌感染的诊断和成功治疗具有重要意义。结论本综述总结了最近用于鉴定人类结核病中 miRNA 生物标志物候选物的替代组织研究，特别关注可重复性和一致性。此外，我们还为生物标志物研究的设计提供帮助，以规避主要陷阱。