Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and experimental experiences, the protective molecular mechanisms of therapeutic hypothermia remain to be elucidated. Therefore, in this brief overview we discuss both the clinical evidence and molecular mechanisms of therapeutic hypothermia in order to provide further insights into this promising intervention.

中文翻译：

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低温诱导的大脑细胞保护机制

治疗性低温是一种有效的细胞保护剂和有希望的干预措施，可改善心脏骤停和新生儿缺氧缺血后患者的预后。然而，尽管我们有临床和实验经验，治疗性低温的保护性分子机制仍有待阐明。因此，在这个简短的概述中，我们讨论了治疗性低温的临床证据和分子机制，以便进一步了解这种有希望的干预措施。