In eukaryotes, the replicative helicase is the large multisubunit CMG complex consisting of the Mcm2–7 hexameric ring, Cdc45, and the tetrameric GINS complex. The Mcm2–7 ring assembles from six different, related proteins and forms the core of this complex. In archaea, a homologous MCM hexameric ring functions as the replicative helicase at the replication fork. Archaeal MCM proteins form thermostable homohexamers, facilitating their use as models of the eukaryotic Mcm2–7 helicase. Here we review archaeal MCM helicase structure and function and how the archaeal findings relate to the eukaryotic Mcm2–7 ring.

中文翻译：

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古细菌MCM蛋白作为真核Mcm2-7解旋酶的类似物，以揭示结构和功能的基本特征。

在真核生物中，复制解旋酶是大型的多亚基CMG复合物，由Mcm2-7六聚环，Cdc45和四聚体GINS复合物组成。Mcm2–7环由六个不同的相关蛋白质组装而成，并构成该复合物的核心。在古细菌中，同源MCM六聚环在复制叉处起复制性解旋酶的作用。古细菌MCM蛋白形成热稳定的同型六聚体，有助于将其用作真核Mcm2-7解旋酶的模型。在这里，我们回顾了古细菌MCM解旋酶的结构和功能，以及古细菌的发现与真核Mcm2-7环的关系。