This paper reports the findings from a pilot study of four patients with medically refractory epilepsy undergoing pre-surgical evaluation with ages ranging from 5 to 17 years. Video electroencephalography recordings and data from a near infrared spectroscopy cerebral/somatic oximeter were gathered and related to electrographic seizure onset and offset as determined by a paediatric epileptologist. All four patients showed haemodynamic changes associated with epileptiform activities. The increased blood flow clearly coincided with epileptiform activity and continued to increase as the epileptiform activity built up. Regional cerebral oxygen saturation increased in the epileptogenic focus, perhaps due to loss of cerebrovascular autoregulation. These findings reinforce that near infrared spectroscopy can potentially be used in a wide spectrum of patients with epilepsy regardless of the underlying brain pathology.

中文翻译：

---

在受试者内研究中使用同步视频脑电图/近红外光谱与发作期和间期癫痫样活动相关的血流动力学反应。

本文报告了一项初步研究的结果，该研究对四名接受手术前评估的医学难治性癫痫患者进行了评估，年龄范围为 5 至 17 岁。视频脑电图记录和来自近红外光谱脑/体血氧饱和度计的数据被收集，并与儿科癫痫病学家确定的电图癫痫发作和偏移相关。所有四名患者均表现出与癫痫样活动相关的血流动力学变化。增加的血流量与癫痫样活动明显一致，并且随着癫痫样活动的增加而继续增加。致痫灶局部脑氧饱和度增加，可能是由于脑血管自动调节功能丧失所致。