Nuclear magnetic resonance is the most important form of molecular spectroscopy in chemistry and biochemistry but it is normally blind to chirality. It was predicted in 2004 that precessing nuclear spins in chiral molecules in a liquid in a strong magnetic field induce a rotating electric polarization that is of opposite sign for enantiomers. This polarization arises from the distortion of the electronic structure by the nuclear magnetic moment in the presence of the strong magnetic field and is equivalent to the linear effect of an electric field on the nuclear shielding tensor. The polarization is strongly enhanced in dipolar molecules through the partial orientation of the permanent dipole through the antisymmetric part of the nuclear magnetic shielding tensor. Alternatively, an applied electric field will induce a chirally sensitive magnetization perpendicular to the field and to the nuclear spin. Progress towards the experimental realization of chiral discrimination by NMR is assessed.

中文翻译：

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NMR光谱中的手性鉴别

核磁共振是化学和生物化学中最重要的分子光谱学形式，但它通常对手性视而不见。2004 年预测，强磁场中液体中手性分子的进动核自旋会引起旋转电极化，而对映异构体的符号相反。这种极化源于强磁场存在下核磁矩对电子结构的扭曲，相当于电场对核屏蔽张量的线性效应。通过永久偶极子通过核磁屏蔽张量的反对称部分的部分取向，在偶极子分子中的极化得到强烈增强。或者，施加的电场将诱导垂直于场和核自旋的手性敏感磁化。评估了通过 NMR 实现手性辨别的实验进展。