To date, most antibodies from combinatorial libraries have been selected purely on the basis of binding. However, new methods now allow selection on the basis of function in animal cells. These selected agonist antibodies have given new insights into the important problem of signal transduction. Remarkably, when some antibodies bind to a given receptor they induce a cell fate that is different than that induced by the natural agonist to the same receptor. The fact that receptors can be functionally pleiotropic may yield new insights into the important problem of signal transduction.

中文翻译：

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来自组合文库的抗体使用功能性受体多效性来调节细胞命运

迄今为止，来自组合文库的大多数抗体都是纯粹根据结合来选择的。然而，新方法现在允许根据动物细胞的功能进行选择。这些选定的激动剂抗体为信号转导的重要问题提供了新的见解。值得注意的是，当一些抗体与给定受体结合时，它们诱导的细胞命运与天然激动剂诱导的相同受体不同。受体可以在功能上具有多效性这一事实可能会对信号转导的重要问题产生新的见解。