We describe the moving wire interface attached to the 1-MV AMS system at LLNL's Center for Accelerator Mass Spectrometry for the analysis of nonvolatile liquid samples as either discrete drops or from the direct output of biochemical separatory instrumentation, such as high-performance liquid chromatography. Discrete samples containing at least a few 10s of nanograms of carbon and as little as 50 zmol 14C can be measured with a 3-5% precision in a few minutes. The dynamic range of our system spans approximately 3 orders in magnitude. Sample to sample memory is minimized by the use of fresh targets for each discrete sample or by minimizing the amount of carbon present in a peak generated by an HPLC containing a significant amount of 14C. Liquid Sample AMS provides a new technology to expand our biomedical AMS program by enabling the capability to measure low-level biochemicals in extremely small samples that would otherwise be inaccessible.

中文翻译：

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直接将小量液体样品耦合到AMS的接口。

我们在LLNL的加速器质谱中心描述了连接到1-MV AMS系统的可动线接口，用于分析非挥发性液体样品的离散滴或直接从生化分离仪器（如高效液相色谱法）中输出。可以在几分钟内以3-5％的精度测量包含至少几十纳克碳和低至50 zmol 14C的离散样品。我们系统的动态范围跨度约为3个数量级。通过为每个离散样品使用新的靶标或通过使包含大量14C的HPLC产生的峰中存在的碳量最小化，可以最大程度地减少样品间的样品记忆。