Obesity is associated with chronic inflammation of various tissues including visceral adipose tissue (VAT), which contributes to insulin resistance. T cells and macrophages infiltrate VAT in obesity and orchestrate this inflammation. Recently, we made the surprising discovery that B cells are important contributors to this process. Thus, some B cells and the antibodies they produce can promote VAT-associated and systemic inflammation, leading to insulin resistance. This report will focus on the properties of these B cells, and how they contribute to insulin resistance through T-cell modulation and production of pathogenic autoantibodies. Understanding the mechanisms by which B cells contribute to insulin resistance should lead to new antibody-based diagnostics and B-cell modulating therapeutics to manage this increasingly prevalent disease.

肥胖与各种组织的慢性炎症有关，包括内脏脂肪组织 (VAT)，这会导致胰岛素抵抗。T 细胞和巨噬细胞在肥胖症中渗入增值税并协调这种炎症。最近，我们惊奇地发现 B 细胞是这一过程的重要贡献者。因此，一些 B 细胞及其产生的抗体可以促进 VAT 相关和全身炎症，导致胰岛素抵抗。本报告将重点关注这些 B 细胞的特性，以及它们如何通过 T 细胞调节和致病性自身抗体的产生来促进胰岛素抵抗。了解 B 细胞导致胰岛素抵抗的机制应该会导致新的基于抗体的诊断和 B 细胞调节疗法来管理这种日益普遍的疾病。