In recent years, advances in metabolic imaging have become dependable tools for the diagnosis and treatment assessment in cancer. Dynamic nuclear polarization (DNP) has recently emerged as a promising technology in hyperpolarized (HP) magnetic resonance imaging (MRI) and has reached clinical relevance with the successful visualization of [1-13C] pyruvate as a molecular imaging probe in human prostate cancer. This review focuses on introducing representative compounds relevant to metabolism that are characteristic of cancer tissue: aerobic glycolysis and pyruvate metabolism, glutamine addiction and glutamine/glutamate metabolism, and the redox state and ascorbate/dehydroascorbate metabolism. In addition, a brief introduction of probes that can be used to trace necrosis, pH changes, and other pathways relevant to cancer is presented to demonstrate the potential that HP MRI has to revolutionize the use of molecular imaging for diagnosis and assessment of treatments in cancer.

中文翻译：

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用动态核极化增强磁共振成像研究癌症代谢的 13C 标记生化探针

近年来，代谢成像的进步已成为癌症诊断和治疗评估的可靠工具。动态核极化 (DNP) 最近已成为超极化 (HP) 磁共振成像 (MRI) 中的一项有前途的技术，并且已与 [1-13C] 丙酮酸作为人类前列腺癌分子成像探针的成功可视化达到临床相关性。本综述重点介绍与癌症组织特征性代谢相关的代表性化合物：有氧糖酵解和丙酮酸代谢、谷氨酰胺成瘾和谷氨酰胺/谷氨酸代谢，以及氧化还原状态和抗坏血酸/脱氢抗坏血酸代谢。此外，简要介绍了可用于追踪坏死、pH 变化、