Biodegradable–biocompatible polyurethanes were prepared with fixed hexamethylene diisocyanate and varying ratios of isomannide and poly(ϵ-caprolactone) diol using a simple one-step polymerization without a catalyst. The polyurethane structures were confirmed by 1H-nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography. The glass transition temperatures were determined by thermal analysis to be between 25°C and 30°C. Degradation tests performed at 37°C in phosphate buffer produced mass losses of 5%–10% after 8 weeks. After 5 days of culture, using osteoblastic cells, the relative cell number on all the polyurethane films was only slightly lower than that of an optimized tissue culture plastic. These polymers offer significant promise with a simplistic synthesis and controlled degradation.

中文翻译：

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含有不同比例的生物基异甘露醇和聚（ε-己内酯）二醇的高强度生物降解聚氨酯的应用

使用固定的六亚甲基二异氰酸酯和不同比例的异甘露醇和聚（ε-己内酯）二醇，使用简单的一步聚合反应制备了可生物降解的生物相容性聚氨酯，无需催化剂。聚氨酯结构由 1 H-核磁共振、傅里叶变换红外光谱和凝胶渗透色谱法证实。通过热分析确定玻璃化转变温度在 25°C 和 30°C 之间。在 37°C 下在磷酸盐缓冲液中进行的降解测试在 8 周后产生了 5%–10% 的质量损失。使用成骨细胞培养 5 天后，所有聚氨酯薄膜上的相对细胞数量仅略低于优化的组织培养塑料。这些聚合物通过简单的合成和可控的降解提供了重要的前景。