How meals containing large amounts of lipids induce insulin resistance in the short and long term remains a topic of intense research. Speakers of the afternoon session showed recent findings on the modulation of mitochondria-induced oxidative stress by energy substrates, both in chronic and acute (single high-fat intake) contexts, which have enabled a better understanding of insulin action at the molecular and cellular levels. These advances are highly amenable to being combined with innovative, elegant imaging techniques to look at the fate of these energy substrates at the in vivo level within optimally defined experimental protocols, both in human and nonhuman models.

含有大量脂质的膳食如何在短期和长期内诱导胰岛素抵抗仍然是一个深入研究的主题。下午会议的演讲者展示了在慢性和急性（单一高脂肪摄入）环境中能量底物调节线粒体诱导的氧化应激的最新发现，这有助于更好地了解分子和细胞水平上的胰岛素作用. 这些进步非常适合与创新、优雅的成像技术相结合，在人类和非人类模型中，在最佳定义的实验方案中，在体内水平上观察这些能量底物的命运。