In the field of autoimmune thyroiditis, NOD.H2h4 mice have attracted significant and increasing attention since they not only develop spontaneous disease but they present thyroiditis with accelerated incidence and severity if they ingest iodide through their drinking water. This animal model highlights the interplay between genetic and dietary factors in the triggering of autoimmune disease and offers new opportunities to study immunoregulatory parameters influenced by both genes and environment. Here, we review experimental findings with this mouse model of thyroiditis.

中文翻译：

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基因和环境作为自身免疫的诱发因素：NOD.H2h4 小鼠膳食碘化物加速自发性甲状腺炎。


在自身免疫性甲状腺炎领域，NOD.H2h4小鼠引起了越来越多的关注，因为它们不仅会发展自发性疾病，而且如果通过饮用水摄入碘，它们会加速甲状腺炎的发病率和严重程度。该动物模型强调了遗传和饮食因素在引发自身免疫性疾病中的相互作用，并为研究受基因和环境影响的免疫调节参数提供了新的机会。在这里，我们回顾了这种甲状腺炎小鼠模型的实验结果。