Although hyperthermophilic archaea arguably have a great need for efficient DNA repair, they lack members of several DNA repair protein families broadly conserved among bacteria and eukaryotes. Conversely, the putative DNA repair genes that do occur in these archaea often do not generate the expected phenotype when deleted. The prospect that hyperthermophilic archaea have some unique strategies for coping with DNA damage and replication errors has intellectual and technological appeal, but resolving this question will require alternative coping mechanisms to be proposed and tested experimentally. This review evaluates a combination of four enigmatic properties that distinguishes the hyperthermophilic archaea from all other organisms: DNA polymerase stalling at dU, apparent lack of conventional NER, lack of MutSL homologs, and apparent essentiality of homologous recombination proteins. Hypothetical damage-coping strategies that could explain this set of properties may provide new starting points for efforts to define how archaea differ from conventional models of DNA repair and replication fidelity.

中文翻译：

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了解高温嗜热古细菌中的DNA修复：持续存在的差距和关注叉子的其他原因。

尽管可以说高温嗜热古菌对有效的DNA修复有很大的需求，但它们缺乏在细菌和真核生物中广泛保存的几种DNA修复蛋白家族的成员。相反，确实存在于这些古细菌中的推定的DNA修复基因在缺失时通常不会产生预期的表型。嗜热古细菌具有一些独特的策略来应对DNA损伤和复制错误的前景具有知识和技术吸引力，但要解决此问题，将需要提出替代的应对机制并通过实验进行测试。这篇评论评估了四种神秘特性的组合，这些特性将超嗜热古细菌与所有其他生物区分开来：DNA聚合酶停滞在dU，明显缺乏常规NER，缺乏MutSL同源物，和同源重组蛋白的表观必要性。可以解释这组特性的假设性破坏应对策略可能会为定义古细菌与传统的DNA修复和复制保真度模型之间的差异提供新的起点。