Caffeic acid phenyl ester (CAPE) is a potent anti-inflammatory agent and it can eliminate the free radicals. This study aimed to investigate the radioprotective effects of CAPE on X-ray irradiation induced intestinal injury in rats. Rats were intragastrically administered with 10 μmol/kg/d CAPE for 7 consecutive days before exposing them to a single dose of X-ray irradiation (9 Gy) to abdomen. Rats were sacrificed 72 h after exposure to radiation. We found that pretreatment with CAPE effectively attenuated intestinal pathology changes, apoptosis, oxidative stress, bacterial translocation, the content of nitric oxide and myeloperoxidase as well as the concentration of plasma tumor necrosis factor-α. Pretreatment with CAPE also reversed the activation of p38MAPK and the increased expression of intercellular cell adhesion molecule-1 induced by radiation in intestinal mucosa. Taken together, these results suggest that pretreatment with CAPE could be a promising candidate for treating radiation-induced intestinal injury.

咖啡酸苯基酯（CAPE）是一种有效的抗炎剂，可以消除自由基。本研究旨在探讨CAPE对X射线辐射引起的大鼠肠道损伤的辐射防护作用。连续7天给大鼠灌胃10μmol/ kg / d CAPE，然后将其暴露于单剂量X射线（9 Gy）腹腔中。暴露于辐射72小时后处死大鼠。我们发现，CAPE预处理可有效减轻肠道病理变化，细胞凋亡，氧化应激，细菌移位，一氧化氮和髓过氧化物酶的含量以及血浆肿瘤坏死因子-α的浓度。CAPE预处理还可以逆转肠粘膜中辐射诱导的p38MAPK激活和细胞间粘附分子1表达的增加。综上，这些结果表明，CAPE预处理可能是治疗放射线引起的肠道损伤的有前途的候选者。