THz Medical Imaging: in vivo Hydration Sensing,IEEE Transactions on Terahertz Science and Technology

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THz Medical Imaging: in vivo Hydration Sensing
IEEE Transactions on Terahertz Science and Technology ( IF 3.9 ) Pub Date : 2011-09-01 , DOI: 10.1109/tthz.2011.2159551
Zachary D Taylor ₁ , Rahul S Singh ₂ , David B Bennett ₃ , Priyamvada Tewari ₄ , Colin P Kealey ₅ , Neha Bajwa ₄ , Martin O Culjat ₂ , Alexander Stojadinovic ₆ , Hua Lee ₇ , Jean-Pierre Hubschman ₈ , Elliott R Brown ₉ , Warren S Grundfest ₁₀

Affiliation

Department of Bioengineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA ( ).
Department of Bioengineering, Department of Surgery, and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
Department of Electrical Engineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
Department of Bioengineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
Department of Surgery and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
Department of Surgery, Walter Reed Army Medical Center and the Combat Wound Initiative Program, Washington, DC 20307 USA.
Department of Electrical and Computer Engineering, University of California at Santa Barbara, Santa Barbara, CA 93106 USA.
Department of Ophthalmology, University of California at Los Angeles, Los Angeles, CA 90095 USA.
Department of Physics, Wright State University, Dayton, OH 45435 USA.
Department of Electrical Engineering, Department of Bioengineering, Department of Surgery, and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.

The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at ~525 GHz center frequency with ~125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models in vivo over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of ex vivo porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.

中文翻译：

太赫兹医学成像：体内水合作用传感

太赫兹在医学成像中的应用正在经历兴趣和联邦资金的激增。提供了该领域的简要概述以及有前途的新兴应用和正在进行的研究。讨论了太赫兹成像现象学并确定了权衡。介绍了一个 THz 医学成像系统，它在 ~525 GHz 中心频率下工作，响应归一化带宽 ~125 GHz，并提供了有关操作原理的详细信息。介绍了太赫兹成像的两个有前途的医学应用：皮肤烧伤和角膜。对于烧伤，在 8 小时内在体内大鼠模型中获得二度、部分厚度烧伤的图像。这些图像清楚地显示了烧伤伤口区域内和周围水肿的形成和进展。对于角膜，

更新日期：2011-09-01

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