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Intelligent system design for bionanorobots in drug delivery.
Cancer Nanotechnology ( IF 5.7 ) Pub Date : 2013-07-14 , DOI: 10.1007/s12645-013-0044-5
Mark Fletcher 1 , Mohammad Biglarbegian 2 , Suresh Neethirajan 3
Affiliation  

A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuzzy logic for diagnosis and treatment of tumors inside the human body using bionanorobots. We utilize fuzzy logic and a combination of thermal, magnetic, optical, and chemical nanosensors to interpret the uncertainty associated with the sensory information. Two different fuzzy logic structures, for diagnosis (Mamdani structure) and for cure (Takagi–Sugeno structure), were developed to efficiently identify the tumors and treat them through delivery of effective dosages of a drug. Validation of the designed system with simulated conditions proved that the drug delivery of bionanorobots was robust to reasonable noise that may occur in the bionanorobot sensors during navigation, diagnosis, and curing of the cancer cells. Bionanorobots represent a great hope for successful cancer therapy in the near future.

中文翻译:

药物输送中生物纳米机器人的智能系统设计。

纳米机器人被定义为能够在纳米尺度上致动,感应,操纵,智能和群体行为的任何智能结构。在这项研究中,我们设计了一种使用模糊逻辑的智能系统,用于使用生物纳米机器人对人体内部的肿瘤进行诊断和治疗。我们利用模糊逻辑以及热,磁,光学和化学纳米传感器的组合来解释与感官信息相关的不确定性。开发了两种不同的模糊逻辑结构,用于诊断(Mamdani结构)和用于治愈(Takagi–Sugeno结构),以有效识别肿瘤并通过有效剂量的药物进行治疗。在模拟条件下对设计系统的验证证明,生物纳米机器人的药物输送对在癌细胞导航,诊断和治愈期间生物纳米机器人传感器中可能出现的合理噪声具有鲁棒性。仿生机器人代表了在不久的将来成功进行癌症治疗的巨大希望。
更新日期:2013-07-14
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