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Green synthesis of gold nanoparticles and their anticancer activity.
Cancer Nanotechnology ( IF 4.5 ) Pub Date : 2013-06-05 , DOI: 10.1007/s12645-013-0040-9
Ravi Geetha 1 , Thirunavukkarasu Ashokkumar 1 , Selvaraj Tamilselvan 1 , Kasivelu Govindaraju 2 , Mohamed Sadiq 3 , Ganesan Singaravelu 1
Affiliation  

As the nano revolution unfolds, it is imperative to integrate nanoscience and medicine. The secret gleaned from nature have led to the generation of biogenic technologies for the fabrication of advanced nanomaterials. Present investigation discloses the gold nanoparticles biosynthesizing capability of the flower of pharmacologically important tree Couroupita guianensis. Rapid, cost-effective, one-step process of synthesis has been achieved. Newly genre gold nanoparticles were characterized by involving UV–vis spectroscopy, FTIR, XRD, SEM, and TEM analysis. Interestingly, as a result of extensive screening on the application of newly synthesized gold nanoparticles their anticancer potential has been discovered using MTT assay, DNA fragmentation, apoptosis by DAPI staining, and comet assay for DNA damage.

中文翻译:

金纳米粒子的绿色合成及其抗癌活性。

随着纳米技术革命的发展,必须将纳米科学与医学结合起来。从自然界中搜集的秘密导致了用于制造高级纳米材料的生物技术的产生。本研究揭示了药理学重要树Couroupita guianensis的花中金纳米颗粒的生物合成能力。已经实现了快速,经济高效的一步合成过程。新类型的金纳米颗粒的特征在于涉及紫外可见光谱,FTIR,XRD,SEM和TEM分析。有趣的是,由于对新合成的金纳米粒子的应用进行了广泛筛选的结果,已使用MTT分析,DNA片段化,DAPI染色的细胞凋亡和彗星试验检测DNA损伤发现了它们的抗癌潜力。
更新日期:2013-06-05
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