Ultraweak intrinsic bioluminescence of cancer cell is a noninvasive method of assessing bioenergetic status of the investigated cells. This weak biophoton emission generated by prostate cancer cells (PC3) was measured in the presence of Ag nanoparticles and its correlation with singlet oxygen production was investigated. The comparison between nanoparticles concentration, bioluminescence intensity, and cell survival showed that Ag nanoparticles do not significantly affect cell survival at used concentration but they increase cell bioluminescent processes. It was also confirmed that singlet oxygen contributes to biophoton emission, that Ag nanoparticles increase this contribution, and that there are secondary mechanisms independent of singlet oxygen by which Ag nanoparticles contribute to increased cellular bioluminescence, possibly through plasmon resonance enhancement of intrinsic fluorescence.

中文翻译：

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Ag纳米颗粒增强前列腺癌细胞的生物光子发射。

癌细胞的超弱固有生物发光是评估所研究细胞生物能状态的一种非侵入性方法。在存在银纳米颗粒的情况下测量了前列腺癌细胞（PC3）产生的这种微弱的生物光子发射，并研究了其与单线态氧产生的相关性。纳米颗粒浓度，生物发光强度和细胞存活率之间的比较表明，Ag纳米颗粒在使用浓度下不会显着影响细胞存活，但会增加细胞生物发光过程。还证实了单线态氧有助于生物光子的发射，Ag纳米粒子增加了这种贡献，并且存在独立于单线态氧的次级机制，Ag纳米粒子通过这种机制促进了细胞的生物发光，