The application of nanomaterial in cancer treatment is promising and intriguing. Anti-tumor immunotherapy has the potential to significantly improve the prognosis of cancer treatment, though the efficacy of immunotherapy generally needs further improvement. One way to improve the efficacy is using immune adjuvants, but the adjuvants for anticancer immunotherapy have to be more potent than for prophylactic vaccines. Here, we report that compared to conventional alum adjuvant, aluminum oxide nanoparticles (nano-alum) may further enhance the anticancer effects of an immunotherapy that employs tumor cell vaccine (TCV). The average tumor size tends to be lower in animals that receive the combinational treatment of nano-alum and TCV. The anticancer cytotoxicity by the lymphocytes was also significantly higher in the treatment group that received both TCV and nano-alum. These results suggest that nano-alum may potentially serve as a potent immune adjuvant and have prospective applications in anticancer immunotherapy.

中文翻译：

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铝纳米颗粒增强了肿瘤细胞疫苗诱导的抗癌免疫反应。

纳米材料在癌症治疗中的应用是有前途的和令人感兴趣的。尽管免疫疗法的疗效通常需要进一步提高，但抗肿瘤免疫疗法具有显着改善癌症治疗预后的潜力。一种提高功效的方法是使用免疫佐剂，但是抗癌免疫疗法的佐剂必须比预防性疫苗更有效。在这里，我们报道与传统的明矾佐剂相比，氧化铝纳米颗粒（纳米）可以进一步增强采用肿瘤细胞疫苗（TCV）的免疫疗法的抗癌作用。在接受纳米明矾和TCV联合治疗的动物中，平均肿瘤大小往往会更低。在同时接受TCV和纳米铝的治疗组中，淋巴细胞的抗癌细胞毒性也明显更高。这些结果表明，纳米铝可能潜在地用作有效的免疫佐剂，并且在抗癌免疫疗法中具有前瞻性的应用。