Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the host to microbial infection and is the leading cause of death in intensive care units. The pathogenesis of sepsis is highly complex. It is principally attributable to dysregulation of the innate immune system. Damage-associated molecular patterns (DAMPs) are actively secreted by innate immune cells and/or released passively by injured or damaged cells in response to infection or injury. In the present review, we highlight emerging evidence that supports the notion that extracellular DAMPs act as crucial proinflammatory danger signals. Furthermore, we discuss the potential of a wide array of DAMPs as therapeutic targets in sepsis.

中文翻译：

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DAMPs激活败血症中的先天免疫应答。

脓毒症是指宿主对微生物感染的有害和无法解决的全身性炎症反应，是重症监护病房的主要死亡原因。败血症的发病机理是高度复杂的。它主要归因于先天免疫系统的失调。与损伤相关的分子模式（DAMP）由先天免疫细胞主动分泌，和/或由受感染或受损的细胞响应感染或伤害而被动释放。在本综述中，我们重点介绍了新兴证据，这些证据支持细胞外DAMP充当至关重要的促炎危险信号的观点。此外，我们讨论了多种DAMPs作为败血症治疗靶标的潜力。