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Site-selective Sonogashira reactions of 1,2-dibromo-3,5-difluorobenzene
Catalysis Communications ( IF 3.4 ) Pub Date : 2012-03-27 , DOI: 10.1016/j.catcom.2012.03.022
Sebastian Reimann , Peter Ehlers , Muhammad Sharif , Kai Wittler , Anke Spannenberg , Ralf Ludwig , Peter Langer

A variety of mono- and diethynyl substituted fluorinated benzene derivatives was prepared by Sonogashira cross coupling reactions of 1,2-dibromo-3,5-difluorobenzene. The reactions proceed with very good site-selectivity in favor of position 1, due to electronic and steric reasons.



中文翻译:

1,2-二溴-3,5-二氟苯的定点Sonogashira反应

通过1,2-二溴-3,5-二氟苯的Sonogashira交叉偶联反应制备了各种单和二乙炔基取代的氟化苯衍生物。由于电子和空间原因,反应以非常好的位点选择性进行,有利于位置1。

更新日期:2012-03-27
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