宾夕法尼亚大学Song Lab 招聘启事

POSTDOCTORAL POSITION IN NEUROSCIENCE

The Song Lab at University of Pennsylvania/Children’s Hospital of Philadelphia is seeking creative and dedicated individuals with a strong passion for research, curiosity and self-motivation. Our lab offers an exciting opportunity to work in a closely collaborative, inspiring and dynamic environment.

The long-term goal of the Song lab is to elucidate the cellular and molecular basis governing the formation, maintenance and function of neural circuits under physiological and pathological conditions. We are particularly interested in understanding how nervous system copes with injury and are developing strategies to promote neuroregeneration. We have established Drosophila injury models, are performing genetic screens to identify pathways regulating regeneration, are testing the evolutionary conservation of the novel regeneration regulators combining with mammalian injury models, and focus on targeting both the intrinsic and extrinsic mechanisms. With a background in neural development, neural circuits and behavior, fly and mouse genetics, injury and neurodegeneration, and tumor models, our lab offers a unique skillset to achieve this goal.

Our lab is focused on three main themes:

1. Elucidating the mechanisms underlying neural degeneration and regeneration

2. Developing fly models for studying human neurodevelopmental disorders

3. Developing fly models for studying tumorigenesis

Visit our lab website for more details http://songlab.research.chop.edu. 

Here is a shortlist of our recent publications:

1. Li F*, Lo TY*, Miles L*, Wang Q*, Noristani HN, Li D, Niu J, Trombley S, Goldshteyn J, Wang C, Wang S, Qiu J, Pogoda K, Mandal K, Brewster M, Rompolas P, He Y, Janmey PA, Thomas GM, Li S, Song Y. The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation. Nat Comm 22;12(1):3845, Jun 2021.

2. Li D*#, Wang Q*, Gong NN, Kurolap A, Feldman HB, Boy N, Brugger M, Grand K, McWalter K, Sacoto MJG, Wakeling E, Hurst J, March ME, Bhoj EJ, Nowaczyk MJM, Gonzaga-Jauregui C, Mathew M, Dava-Wala S, Siemon A, Bartholomew D, Huang Y, Lee H, Martinez JA, Schwaibold EMC, Brunet T, Choukair D, Pais LS, White SM, Christodoulou J, Brown D, Lindstrom K, Grebe T, Tiosano D, Kayser MS, Tan TY, Deardorff MA, Song Y#, Hakonarson A. Pathogenic variants in SMARCA5, a chromatin remodeler, cause a range of syndromic neurodevelopmental features. Science Advances 12;7(20):eabf2066, May 2021. #Co-corresponding authors. 

3. Li F, Sami A, Noristani HN, Slattery K, Qiu J, Groves T, Wang S, Veerasammy K, Chen YX, Morales J, Hanes P, Sehgal A, He Y, Li S#, and Song Y#. Glial metabolic reprograming promotes axon regeneration and functional recovery in the central nervous system. Cell Metabolism 32(5): 767-785, November 2020.

4. Wang Q, Fan H, Li F, Sharum SR, Krishnamurthy V, Song Y#, Zhang K#. Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila. eLife 9, October 2020. #Co-corresponding authors.

5. Muir AM, Cohen JL, Sheppard SE, Guttipatti P, Lo TY, Weed N, Doherty D, Fagerberg C, Kjærsgaard L, Larsen MJ, Wemmenhove-Lohner K, Hirsh Y, Zeevi DA, Zackai EH, Bhoj E, Song Y#, Mefford HC#. Bi-allelic Loss-of-Function Variants in NUP188 Cause a Recognizable Syndrome Characterized by Neurologic, Ocular, and Cardiaac Abnormalities. Am J Hum Genet. 106(5): 623-631, May 2020. #Co-corresponding authors.

6. Monahan Vargas EJ*, Matamoros AJ*, Qiu J*, Jan CH, Wang Q, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S and Song Y. The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration. Genes and Development 34(3-4): 194-208, February 2020.

7. Song Y#, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Yang X, Rompolas P, Jan LY, Jan YN#. The mechanosensitive ion channel Piezo inhibits axon regeneration. Neuron 102(2): 373-389, February 2019. #Co-corresponding authors.

Successful candidates will benefit from the thriving and collegial UPenn/CHOP research community, tailored career development guidance, state-of-the-art research facilities and excellent benefits packages. Applicants should have a PhD and/or MD degree, and background in fly genetics, mammalian injury models or bioinformatics is highly recommended. Prospective applicants should send a brief statement of research, CV and the names and contact information of three references to Yuanquan Song at songy2@chop.edu.

It is your accomplishment that leads to the success of the lab!

Yuanquan Song, Ph.D.

Assistant Professor, Department of Pathology & Laboratory Medicine

Perelman School of Medicine, University of Pennsylvania

The Raymond G. Perelman Center for Cellular and Molecular Therapeutics

The Children's Hospital of Philadelphia

Philadelphia, PA 19104 songy2@chop.edu