RSC主编推荐：有机领域精彩文章快览（免费阅读原文）

英国皇家化学会（RSC）是一个超过175年历史的面向全球化学家的非营利会员制机构，旗下拥有44种期刊，其中很多在化学领域有很高影响力。为了进一步帮助广大读者追踪科技前沿热点，X-MOL团队与英国皇家化学会合作，推出英国皇家化学会期刊主编推荐的精彩文章快览，本期文章属“有机领域”，英文点评来自英国皇家化学会期刊的主编。如果大家对我们的解读有更多的补充和点评，欢迎在文末写评论发表您的高见！

Chemical Science (IF: 9.063)

1. De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosa

Chem. Sci., 2019, Advance Article

DOI: 10.1039/C9SC01405E

Scientists at Peking University report the first total synthesis and isolation of pseudopaline, which is a metallophore produced by P. aeruginosa. This total synthesis allowed the researchers to determine the absolute and relative configurations of the natural product. The synthesis was carried out in 8 steps, with an asymmetric Tsuji-Trost allylation being a key step to introduce stereocontrol.

北京大学的研究人员首次报道了pseudopaline的全合成与分离，这是一种由铜绿假单胞菌产生的金属团。研究人员们通过全合成确定了该天然产物的绝对和相对构型。合成共计八步，其中不对称Tsuji-Trost烯丙基化是引入立体控制的关键步骤。

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2. Ligand and counteranion enabled regiodivergent C–H bond functionalization of naphthols with α-aryl-α-diazoesters

Chem. Sci., 2019, Advance Article

DOI: 10.1039/C9SC01657K

Researchers at East China Normal University describe a regiodivergent strategy for the direct C-H functionalisation of unprotected naphthols with α-aryl-α-diazoesters. They achieve excellent site-selectivity by controlling the interactions between the hydroxy group and gold catalyst. This work presents a new strategy that can be used in C-H bond functionalisation.

华东师范大学的研究人员介绍了一种区域选择性策略，使用α-芳基-α-重氮酯对无保护的萘酚进行直接的C-H键官能化。他们通过控制羟基和金催化剂之间的相互作用实现了优异的位点选择性。这项工作提出了一种可用于C-H键官能化的新策略。

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Organic Chemistry Frontiers (IF: 5.455)

1. Visible-light-mediated hydrodehalogenation and Br/D exchange of inactivated aryl and alkyl halides with a palladium complex

Org. Chem. Front., 2019, Advance Article

DOI：10.1039/C9QO00240E

Herein, a novel photo-induced amine-free radical reductive dehalogenation of inactivated aryl/alkyl bromides and chlorides with a palladium complex is described, which reveals excellent functional group compatibility and broad substrate scope. Extensional transformations for reductive cyclization, dehalogenative deuteration, and intra- and intermolecular radical addition can be achieved smoothly. Mechanistic studies indicate a single-electron photoredox catalytic system with inactivated solvent as the hydrogen atom donor.

本文描述了钯配合物存在下非活化芳基/烷基溴化物和氯化物的新型光致无胺自由基还原脱卤反应，具有优异的官能团兼容性和广泛的底物范围。可以平稳地实现还原环化、脱卤氘化以及分子内和分子间自由基加成等的延伸转化。机理研究表明了单电子光氧化还原催化体系，以非活化溶剂作为氢原子供体。

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2. A pore-expanded supramolecular organic framework and its enrichment of photosensitizers and catalysts for visible-light-induced hydrogen production

Org. Chem. Front., 2019, Advance Article

DOI:10.1039/C9QO00382G

A pore-expanded three-dimensional supramolecular organic framework SOF-bpb, with a previously unattained aperture size of 3.6 nm, has been constructed in water from the co-assembly of cucurbit[8]uril (CB[8]) and a tetraphenylmethane-cored 1,4-bis(pyridin-4-yl)-benzene-appended building block M1. SOF-bpb can adsorb anionic and neutral Ru²⁺complex photosensitizers and anionic Wells–Dawson-type and Keggin-type polyoxometalates (POMs). The adsorption leads to an important enrichment effect, which remarkably increases the catalytic efficiency of the Ru²⁺ complex–POM systems for visible light-induced reduction of protons to produce H₂.

本文作者通过葫芦[8]脲（CB[8]）以及基于四苯基甲烷核和1,4-双（吡啶-4-基）-苯基团的结构单元M1在水中共组装构建了孔隙扩展的三维超分子有机骨架SOF-bpb，其具有前所未有的3.6 nm孔径。SOF-bpb可以吸附阴离子和中性Ru²⁺配合物光敏剂，以及阴离子Wells-Dawson型和Keggin型多金属氧酸盐（POMs）。通过吸附引发重要的富集效应，能显著提高Ru²⁺配合物-POM系统的催化效率，用于可见光诱导的质子还原反应产生氢气。

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