Inorganic phosphate cements have become prevalent as bone filling materials in clinical applications, owing to beneficial properties such as self-setting, biodegradability and osteoconductivity. However, the further development of phosphate cements with higher strength and improved cytocompatibility is expected. In this paper, we reported the preparation of a novel magnesium phosphate based cement (MPBC), which has similar compositions with magnesium phosphate cement (MPC) but Ca(H₂PO₄)₂·H₂O and citric acid were additionally added to modulate the performance. The physicochemical and biological properties of MPBC were investigated, the influences of the added Ca(H₂PO₄)₂·H₂O and citric acid on the performances of MPBC were analyzed, and the differences of performance between MPBC and MPC were discussed. Experimental results show that the setting time and compressive strength of MPBC were effectively enhanced by the addition of citric acid. In vitro biological degradation indicates that about 15 wt% of MPBC was reduced in 4 weeks. Compared with MPC, MPBC has weaker alkalinity and less dissolution of phosphate, leading to better suitability for cell proliferation and adhesion. These results suggest that as a bone filling material, MPBC shows better performance than MPC in many key indicators and has promising application prospects.

由于有益的特性，例如自固化，生物降解性和骨传导性，无机磷酸盐水泥在临床应用中已成为骨填充材料。但是，期望进一步开发具有更高强度和改善的细胞相容性的磷酸盐水泥。在本文中，我们报道了一种新型的磷酸镁基水泥（MPBC）的制备，其成分与磷酸镁水泥（MPC）相似，但另外添加了Ca（H ₂ PO ₄）₂ ·H ₂ O和柠檬酸。调节性能。研究了MPBC的理化和生物学特性，研究了Ca（H ₂ PO ₄）₂的添加对MPBC的影响。·分析了H ₂ O和柠檬酸对MPBC性能的影响，并探讨了MPBC与MPC之间的性能差异。实验结果表明，添加柠檬酸可有效提高MPBC的凝固时间和抗压强度。体外生物降解表明MPBC在4周内减少了约15 wt％。与MPC相比，MPBC的碱度较弱，磷酸盐的溶解度较低，因此更适合细胞增殖和粘附。这些结果表明，作为骨填充材料，MPBC在许多关键指标上表现出比MPC更好的性能，并具有广阔的应用前景。