The development of an effective technique for detecting antibiotic drug remains a serious task due to their toxicity to public health. For this purpose, herein, we report an electrochemical detection based on Cu₂S nanospheres decorated reduced graphene oxide (RGO@Cu₂S NC) nanocomposite. A sonochemical-assisted method was adopted to prepare the nanocomposite. Subsequently, it’s morphological, elemental, and crystal structural aspects were analyzed. The electrochemical properties were examined in order to ensure the material’s suitability in electrocatalytic sensing. RGO@Cu₂S NC affixed screen-printed electrode found to exhibit tremendous electrocatalytic capability toward chloramphenicol (CAP) reduction. A sensitive and reproducible amperometric CAP sensor was fabricated which able to detect concentration as the nanomolar level. The method is worked well even in real samples (fresh milk samples) and the results are evaluated by HPLC method and amperometric methods.

由于抗生素对公众健康的毒性，开发一种检测抗生素药物的有效技术仍然是一项艰巨的任务。为此，在本文中，我们报告了一种基于Cu ₂ S纳米球修饰的氧化石墨烯（RGO @ Cu ₂ S NC）纳米复合材料的电化学检测方法。采用声化学辅助方法制备了纳米复合材料。随后，对其形态，元素和晶体结构方面进行了分析。为了确保材料在电催化传感中的适用性，对电化学性能进行了检查。RGO @铜₂S NC固定的丝网印刷电极发现对氯霉素（CAP）还原具有巨大的电催化能力。制作了一个灵敏且可重现的安培CAP传感器，该传感器能够检测浓度为纳摩尔水平的浓度。即使在真实样品（鲜牛奶样品）中，该方法也能很好地工作，并通过HPLC法和安培法对结果进行评估。