A simple ultrasonic energy assisted synthesis of β-cyclodextrin (β-CD) supported carbon nanofiber composite (CNF) and its potential application in electrochemical sensing of antibiotic nitrofurantoin (NFT) is reported. The elemental composition, and surface morphology of the β-CD/CNF composite was validated through Field emission scanning electron microscopy, energy dispersive X-ray microscopy, Fourier transformer infrared microscopy, X-ray photoelectron microcopy and thermogravimetric analysis. The uniform enfolding of hydrophilic β-CD over CNF enhance the aqueous dispersion and offer abundant active surface to the β-CD/CNF composite. Further, the electrocatalytic efficacy of the β-CD/CNF composite is utilized to fabricate an electrochemical sensor for the high sensitive quantitative detection of NFT. Under optimized analytical conditions, the sensor displays a broad working range of 0.004-308 µM and calculated detection limit of 1.8 nM, respectively. In addition, the sensor showcased a good selectivity, storage and working stability, with amiable reproducibility. The point-of-care applicability of the sensor was demonstrated with NFT spiked human blood serum, and urine sample with reliable analytical performance. The simple, cost effective NFT sensor based on β-CD/CNF offered outstanding analytical performance in real world samples with higher reliability.

报道了一种简单的超声能量辅助合成的β-环糊精（β-CD）负载的碳纳米纤维复合材料（CNF）及其在抗生素呋喃妥因（NFT）的电化学传感中的潜在应用。通过场发射扫描电子显微镜，能量色散X射线显微镜，傅立叶变换红外光谱，X射线光电子显微镜和热重分析验证了β-CD/ CNF复合材料的元素组成和表面形态。亲水性β-CD在CNF上的均匀包裹增强了水分散体，并为β-CD/ CNF复合材料提供了丰富的活性表面。另外，利用β-CD/ CNF复合物的电催化功效来制造用于NFT的高灵敏定量检测的电化学传感器。在优化的分析条件下，该传感器的工作范围为0.004-308 µM，计算出的检出限分别为1.8 nM。此外，该传感器具有良好的选择性，储存性和工作稳定性，并具有可复制性。NFT加标的人血清和尿液样品具有可靠的分析性能，证明了该传感器的即时适用性。基于β-CD/ CNF的简单，经济高效的NFT传感器以较高的可靠性在现实世界的样品中提供了出色的分析性能。和尿液样品具有可靠的分析性能。基于β-CD/ CNF的简单，经济高效的NFT传感器以较高的可靠性在现实世界的样品中提供了出色的分析性能。和尿液样品具有可靠的分析性能。基于β-CD/ CNF的简单，经济高效的NFT传感器以较高的可靠性在现实世界的样品中提供了出色的分析性能。