Whether new neurons are added to the human brain in childhood or adulthood is of widespread interest. Our recent observations suggest that newborn neurons in the adult human hippocampus (HP) are absent or very rare (Sorrells et al., 2018). A subsequent study proposes that large numbers of new neurons continue to be produced in the adult human HP (Boldrini et al., 2018Boldrini M.Fulmore C.A.Tartt A.N.Simeon L.R.Pavlova I.Poposka V.Rosoklija G.B.Stankov A.Arango V.Dwork A.J.et al.Human hippocampal neurogenesis persists throughout aging.Cell Stem Cell.2018;22:589-599.e5AbstractFull TextFull Text PDFPubMedScopus (49)Google Scholar). This has stimulated discussion and re-appraisal of this topic. Human studies have intractable caveats, making it important to interpret both positive and negative observations, including our own work, with a critical lens. A recent minireview (Kempermann et al., 2018Kempermann G.Gage F.H.Aigner L.Song H.Curtis M.A.Thuret S.Kuhn H.G.Jessberger S.Frankland P.W.Cameron H.A.et al.Human adult neurogenesis: evidence and remaining questions.Cell Stem Cell.2018;23:25-30AbstractFull TextFull Text PDFScopus (0)Google Scholar) attempts to offer a perspective on the field and discusses the challenges of working with human tissue. Yet it fails to critically evaluate the evidence for adult human hippocampal neurogenesis and how, for example, halogenated thymidine analogs or carbon 14 (14C) birthdating are susceptible to false positives or sample processing effects (Extended Discussion inSorrells et al., 2018Sorrells S.F.Paredes M.F.Cebrian-Silla A.Sandoval K.Qi D.Kelley K.W.James D.Mayer S.Chang J.Auguste K.I.et al.Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.Nature.2018;555:377-381CrossrefPubMedScopus (79)Google Scholar). Human Hippocampal Neurogenesis Persists throughout AgingBoldrini et al.Cell Stem CellApril 05, 2018In BriefFull-TextPDFHuman Adult Neurogenesis: Evidence and Remaining QuestionsKempermann et al.Cell Stem CellApril 19, 2018In BriefIn BriefFull-TextPDFConsiderations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human BrainTartt et al.Cell Stem CellDecember 06, 2018In BriefIn BriefFull-TextPDF

中文翻译：

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成人神经发生是否持续存在于人类海马体中？


新的神经元是否在儿童期或成年期被添加到人类大脑中引起了广泛的兴趣。我们最近的观察表明，成人海马体 (HP) 中的新生神经元不存在或非常罕见 (Sorrells et al., 2018)。随后的研究提出，成人 HP 中继续产生大量新神经元（Boldrini et al., 2018Boldrini M.Fulmore CATartt ANSimeon LRPavlova I.Poposka V.Rosoklija GBStankov A.Arango V.Dwork AJet al.Human hippocampal神经发生在整个衰老过程中持续存在。Cell Stem Cell.2018;22:589-599.e5AbstractFull Text全文PDFPubMedScopus (49)Google Scholar)。这引发了人们对这个话题的讨论和重新评价。人类研究有一些棘手的警告，因此用批判性的视角解释积极和消极的观察结果（包括我们自己的工作）非常重要。最近的小型评论（Kempermann 等人，2018Kempermann G.Gage FHAigner L.Song H.Curtis MAThuret S.Kuhn HGJessberger S.Frankland PWCameron HAet al.人类成人神经发生：证据和剩余问题。细胞干细胞.2018；23:25 -30AbstractFull TextFull Text PDFScopus (0)Google Scholar) 试图提供该领域的视角并讨论处理人体组织的挑战。然而，它未能严格评估成人海马神经发生的证据，以及卤化胸苷类似物或碳 14 (14C) 生日如何容易受到假阳性或样本处理影响的影响（Sorrells 等人的扩展讨论，2018Sorrells SFParedes MFCebrian- Silla A.Sandoval K.Qi D.Kelley KWJames D.Mayer S.Chang J.Auguste KIet al.人类海马神经发生在儿童中急剧下降到成人中检测不到的水平。自然。2018；555：377-381CrossrefPubMedScopus（79）谷歌学术）。人类海马神经发生在整个衰老过程中持续存在Boldrini等人。细胞干细胞2018年4月5日简报全文PDF人类成人神经发生：证据和剩余问题Kempermann等人。细胞干细胞2018年4月19日简报简报全文PDF评估成人和衰老过程中海马神经发生程度的考虑因素人类大脑塔特等人。细胞干细胞2018年12月06日简介简介全文PDF